Thirteen NICUs participated in PQCNC CABSI. The primary outcome measure, the effect of interventions on CLABSI rates, was evaluated by measuring changes in quarterly collaborative NHSN rates with a baseline starting in January 2009. The CLABSI rate for all 13 centers showed a significant decline during the initiative from a mean of 5.1 infections/1000 line days to a mean of 1.7 infections/1000 line days through the quarter following the intervention. This represented a reduction of 66% in the collaborative CLABSI rate